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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1467099Generated: October 26, 2026

1,4-Benzodioxane-6-carboxylic Acid → (S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido) butoxy)-2-methylquinoline-3-carboxylate

https://huagongshe.com/reaction/1467099

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Benzodioxane-6-carboxylic AcidHCID 2758833—
Reactant(S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylateHCID 86658218—
Product(S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido) butoxy)-2-methylquinoline-3-carboxylateHCID 86658224—

Reaction Steps

Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate (Example 97b) and 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid as brown solid (46%). MS 480 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000054B2
Source datasetuspto-grants-2015_04
ORD IDord-b36f43ea17a048349cce02eb75332535
Source noteuspto-grants-2015_04