Ethyl Acetoacetate → HCID 66746511, compound

HRID 1467129Notes

Reaction equation

C([O:4][CH2:5][C:6]([CH3:19])([CH3:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[C:10]=1[C:16]#[N:17])(=O)C.O=[C:21]([CH3:28])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[NH2:17][C:16]1[C:10]2[C:11](=[CH:12][CH:13]=[CH:14][C:9]=2[O:8][CH2:7][C:6]([CH3:18])([CH3:19])[CH2:5][OH:4])[N:15]=[C:21]([CH3:28])[C:22]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66747072HCID 66747072, compound

Product 1

HCID 66746511HCID 66746511, compound

Procedure

Prepared as in Example 2a from 3-(3-amino-2-cyanophenoxy)-2,2-dimethylpropyl acetate (Tachdjian, C. et al. PCT Int. App. 2008, WO 2008154221) and ethyl 3-oxobutanoate as a pale yellow solid (26%). MS 333 (MH+).

Sources & evidence

ORD record: ord-be461b6b7e694c518124cca157b32170
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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