Ethyl Acetoacetate → HCID 66746512, compound

HRID 1467131Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][C@@H:11]2[CH2:16][C@H:15]([CH3:17])[CH2:14][CH2:13][C@H:12]2[CH:18]([CH3:20])[CH3:19])[C:3]=1[C:4]#[N:5].O=[C:22]([CH3:29])[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][C:6]=2[O:10][C@@H:11]2[CH2:16][C@H:15]([CH3:17])[CH2:14][CH2:13][C@H:12]2[CH:18]([CH3:20])[CH3:19])[N:1]=[C:22]([CH3:29])[C:23]=1[C:24]([O:26][CH2:27][CH3:28])=[O:25]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66746507HCID 66746507, compound

Product 1

HCID 66746512HCID 66746512, compound

Procedure

Prepared as in Example 2a from 2-amino-6-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)benzonitrile (Example 122b) and ethyl 3-oxobutanoate as a pale yellow solid (43%). MS 385 (MH+).

Sources & evidence

ORD record: ord-5846a31c32c0438684462fbf7ec9e2d3
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

Loading…