Ethyl Acetoacetate → HCID 66745714, compound

HRID 1467148Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH:13]=[CH:12]2)[C:3]=1[C:4]#[N:5].O=[C:18]([CH3:25])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[NH2:5][C:4]1[C:3]2[C:6]3[O:10][CH:11]4[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]4[C:7]=3[CH:8]=[CH:9][C:2]=2[N:1]=[C:18]([CH3:25])[C:19]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 66746549HCID 66746549, compound

Product 1

HCID 66745714HCID 66745714, compound

Procedure

Prepared as in Example 2a from 2-amino-6-(cyclohex-2-en-1-yloxy)benzonitrile (Example 131b) and ethyl 3-oxobutanoate as a pale yellow solid (11%). MS 327 (MH+).

Sources & evidence

ORD record: ord-6ccf1f1748b24c64b01091bc98dd3bf9
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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