2-Cyclohexen-1-OL → HCID 66746549, compound

HRID 1467149Notes

Reaction equation

HRID 1467149 reaction equation
[CH:1]1([OH:7])[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]1.[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13](F)[C:10]=1[C:11]#[N:12]>>[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([O:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]2)[C:10]=1[C:11]#[N:12]

Participants

3

Reactant 2

HCID 131982-Cyclohexen-1-OLHCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 66746549HCID 66746549, compound

Procedure

Prepared as in Example 22b from cyclohex-2-enol and 2-amino-6-fluorobenzonitrile as a colorless oil (78%). 1H NMR (400 MHz, CDCl3) δ 1.64 (m, 1H), 1.96 (m, 4H), 2.15 (m, 1H), 4.39 (s, 2H), 4.82 (m, 1H), 5.87 (m, 1H), 5.98 (m, 1H), 6.30 (d, 2H), 7.20 (t, 1H). MS 215 (MH+).

Sources & evidence

ORD record
ord-82ad7127ee564026970d77a3a68323c1
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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