Cyclobutanecarboxylic acid → HCID 66745951, compound

HRID 1467162Notes

Reaction equation

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C:14]([NH2:17])([CH3:16])[CH3:15])[N:5]=[C:4]([CH3:18])[C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].[CH:24]1([C:28](O)=[O:29])[CH2:27][CH2:26][CH2:25]1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C:14]([NH:17][C:28]([CH:24]2[CH2:27][CH2:26][CH2:25]2)=[O:29])([CH3:16])[CH3:15])[N:5]=[C:4]([CH3:18])[C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

Reactant 2

HCID 19494Cyclobutanecarboxylic acid

HCID 66746535HCID 66746535, compound

Product 1

HCID 66745951HCID 66745951, compound

Procedure

Prepared as in Example 24a from ethyl 4-amino-5-(2-amino-2-methylpropoxy)-2-methylquinoline-3-carboxylate (Example 24b) and cyclobutanecarboxylic acid as an off-white solid (61%). MS 400 (MH+).

Sources & evidence

ORD record: ord-2ccaf710e66948a89cb9e5b6d973b1b6
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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