HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-3-(Boc-amino)-1-phenyl-piperidine | HCID 70652814 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (3R)-1-phenylpiperidin-3-amine | HCID 70652306 | — |
Reaction Steps
A solution of tert-butyl [(3R)-1-phenylpiperidin-3-yl]carbamate (133 mg, 0.483 mmol) in 3 M HCl in MeOH (3 ml) was heated to 70° C. for 3 hr. The reaction mixture was concentrated in vacuo to provide crude (3R)-1-phenylpiperidin-3-amine as the bis HCl salt, which was used as-is without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999957B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-14f36128afe04dfba23dc66a4b1e28c8 |
| Source note | uspto-grants-2015_04 |