Hydrochloric Acid → Hydrochloric Acid

HRID 1467310Notes

Reaction equation

HRID 1467310 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][CH2:10][C@@H:9]([NH:13]C(=O)OC(C)(C)C)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]>CO>[C:1]1([N:7]2[CH2:12][CH2:11][CH2:10][C@@H:9]([NH2:13])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70652814(R)-3-(Boc-amino)-1-phenyl-piperidine

Product 2

HCID 313Hydrochloric AcidHCID 70652306(3R)-1-phenylpiperidin-3-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of tert-butyl [(3R)-1-phenylpiperidin-3-yl]carbamate (133 mg, 0.483 mmol) in 3 M HCl in MeOH (3 ml) was heated to 70° C. for 3 hr. The reaction mixture was concentrated in vacuo to provide crude (3R)-1-phenylpiperidin-3-amine as the bis HCl salt, which was used as-is without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-14f36128afe04dfba23dc66a4b1e28c8
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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