Dichloromethane → HCID 67995855, compound

HRID 1467316Notes

Reaction equation

HRID 1467316 reaction equation
[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([NH:11]C(=O)OC(C)(C)C)[C:6]1=[O:19].ClCCl.FC(F)(F)C(O)=O>C1(C)C=CC=CC=1>[NH2:11][CH:7]1[CH2:8][CH2:9][CH2:10][N:5]([CH2:4][C:3]2[C:20]([O:24][CH3:25])=[CH:21][CH:22]=[CH:23][C:2]=2[F:1])[C:6]1=[O:19]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86681278HCID 86681278, compound

Product 1

HCID 67995855HCID 67995855, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The synthetic intermediate from Step 1 (329 mg, 0.934 mmol), dichloromethane (1 ml), and trifluoroacetic acid (1 ml) were combined in an open vial, and the mixture was allowed to stir for 1 hour. The mixture was then diluted with toluene (3 ml) and subsequently concentrated to dryness. Crude (3-amino-1-(2-fluoro-6-methoxybenzyl)piperidin-2-one so obtained was used in the next synthetic transformation without additional purification.

Workup

  1. concentrationsubsequently concentrated to dryness

Sources & evidence

ORD record
ord-e02035e5b827476ca9cb5fd49393e430
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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