Methanol → HCID 67996377, compound

HRID 1467344Notes

Reaction equation

HRID 1467344 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:16]([O:18]C)=[O:17])[CH:14]=3)[NH:9][N:8]=2)=[CH:3][CH:2]=1.[OH-].[K+:21].CO.O>C1COCC1>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:16]([O-:18])=[O:17])[CH:14]=3)[NH:9][N:8]=2)=[CH:3][CH:2]=1.[K+:21]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 14797Potassium Hydroxide2×HCID 67996212HCID 67996212, compound

Product 1

HCID 67996377HCID 67996377, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

Methyl 3-pyridin-4-yl-1H-indazole-5-carboxylate (305 mg, 1.204 mmol) and KOH (88 mg, 1.566 mmol) were stirred in THF (9 mL)/MeOH (1.5 mL)/water (1.5 mL) at 70° C. for 24 hours. Additional KOH (87 mg, 1.551 mmol) was added and stirring at 70° C. continued for 20 hours. Room temperature was attained and the solvent was removed in vacuo to give potassium 3-(pyridin-4-yl)-1H-indazole-5-carboxylate as a brown solid (˜67 wt %).

Workup

  1. customRoom temperature
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d35bdd449f86436e87f5d22d39025951
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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