Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

tert-Butyl (3R)-1-(2-(dimethylamino)-1-(2-fluorophenyl)-2-oxoethyl)piperidin-3-ylcarbamate (302 mg, 0.796 mmol), prepared according to the procedures described for tert-butyl (3R)-1-(2-amino-1-(2-fluorophenyl)-2-oxoethyl)piperidin-3-ylcarbamate, was stirred in 3 M HCl in MeOH (8 mL) at 50° C. for 5 hours. The solvent was removed in vacuo to give the bis HCl salt of 2-((R)-3-aminopiperidin-1-yl)-2-(2-fluorophenyl)-N,N-dimethylacetamide as a ˜1:1 mixture of diastereoisomers.

Provenance & Evidence