Hydrochloric Acid → Hydrochloric Acid

HRID 1467345Notes

Reaction equation

HRID 1467345 reaction equation
[CH3:1][N:2]([CH3:27])[C:3](=[O:26])[CH:4]([N:12]1[CH2:17][CH2:16][CH2:15][C@@H:14]([NH:18]C(=O)OC(C)(C)C)[CH2:13]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11].NC(=O)C(N1CCC[C@@H](NC(=O)OC(C)(C)C)C1)C1C=CC=CC=1F.[ClH:53]>CO>[ClH:53].[NH2:18][C@@H:14]1[CH2:15][CH2:16][CH2:17][N:12]([CH:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[F:11])[C:3]([N:2]([CH3:27])[CH3:1])=[O:26])[CH2:13]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 70652350HCID 70652350, compoundHCID 86681286HCID 86681286, compound

Product 2

HCID 313Hydrochloric AcidHCID 86681285HCID 86681285, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

tert-Butyl (3R)-1-(2-(dimethylamino)-1-(2-fluorophenyl)-2-oxoethyl)piperidin-3-ylcarbamate (302 mg, 0.796 mmol), prepared according to the procedures described for tert-butyl (3R)-1-(2-amino-1-(2-fluorophenyl)-2-oxoethyl)piperidin-3-ylcarbamate, was stirred in 3 M HCl in MeOH (8 mL) at 50° C. for 5 hours. The solvent was removed in vacuo to give the bis HCl salt of 2-((R)-3-aminopiperidin-1-yl)-2-(2-fluorophenyl)-N,N-dimethylacetamide as a ˜1:1 mixture of diastereoisomers.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-299a3ddc18d549b3aff424f069aa9d93
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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