Hydrochloric Acid → Hydrochloric Acid

HRID 1467350Notes

Reaction equation

HRID 1467350 reaction equation
C(OC([NH:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][N:11]([C@@H:15]([C:20]2[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=2[F:27])[C:16]([O:18][CH3:19])=[O:17])[CH2:10]1)=O)(C)(C)C.[ClH:28]>CO>[ClH:28].[NH2:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][N:11]([C@@H:15]([C:20]2[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=2[F:27])[C:16]([O:18][CH3:19])=[O:17])[CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70652638HCID 70652638, compound

Product 2

HCID 313Hydrochloric AcidHCID 67996993HCID 67996993, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-Methyl 2-((R)-3-(tert-butoxycarbonylamino)piperidin-1-yl)-2-(2,6-difluorophenyl)acetate (185 mg, 0.481 mmol) was stirred in 3 M HCl in MeOH (5 mL) at room temperature for 24 hours and at 50° C. for 5 hours. The solvent was removed in vacuo to give the bis HCl salt of (5)-methyl 2-((R)-3-aminopiperidin-1-yl)-2-(2,6-difluorophenyl)acetate as a beige solid.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-050216fd77c648499ec00ccc71e0b8cd
Source dataset
uspto-grants-2015_04
Patent number
US08999957B2

Reaction notes

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