1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene → HCID 68987285, compound

HRID 1467870Notes

Reaction equation

HRID 1467870 reaction equation
[CH:1]1([N:4]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1.Br[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:24][CH:23]=1>>[CH:1]1([N:4]([CH:14]2[CH2:19][CH2:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:24][CH:23]=3)[CH2:16][CH2:15]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)(=[O:6])=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 878361-(Bromomethyl)-4-(1,1-dimethylethyl)benzeneHCID 2735904387350-82-5

Product 1

HCID 68987285HCID 68987285, compound

Procedure

Also, N-cyclopropyl-N-[1-(4-tert-butylbenzyl)piperidin-4-yl]-benzenesulfonamide was prepared from N-cyclopropyl-N-piperidin-4-yl-benzenesulfonamide and 1-bromomethyl-4-tert-butylbenzene. LC: 100%, MS: m/z=427.2, 428.3 (M+H+). 1H NMR (400 MHz, CDCl3): δ 7.85 (2H, m), 7.56 (1H, m), 7.50 (2H, m), 7.32 (2H, d, J=8.4 Hz), 7.19 (2H, d, J=8.4 Hz), 3.85 (1H, m), 3.44 (2H, s), 2.89 (1H, s), 2.87 (1H, s), 1.97 (5H, m), 1.59 (4H, s), 1.49 (1H, s), 1.47 (1H, s), 1.32 (9H, s), 0.97 (2H, m), 0.75 (2H, m).

Sources & evidence

ORD record
ord-a1fd34d3d57b4726954ede6720d90bad
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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