Piperidine → HCID 68984175, compound

HRID 1467881Notes

Reaction equation

HRID 1467881 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:30])[CH:25]=[CH:26][CH2:27][CH2:28][CH3:29])[CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1.[NH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:24](=[O:30])[CH2:25][CH:26]([N:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[CH2:27][CH2:28][CH3:29])[CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:16])[F:17])[CH:9]=2)(=[O:6])=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 68983635HCID 68983635, compound

Product 1

HCID 68984175HCID 68984175, compound

Procedure

By following the procedure described above, N-cyclopropyl-N-(1-hex-2-enoyl-piperidin-4-yl)-3-trifluoromethylbenzenesulfonamide (30) was reacted with piperidine and N-cyclopropyl-N-{1-[3-(piperidin-1-yl)hexanoyl]piperidin-4-yl}-3-trifluoromethylbenzenesulfonamide (32) was obtained as a white solid. 1H NMR (CDCl3): δ 8.15 (S, 1H), 8.06 (d, 1H), 7.87 (d, 1H), 7.71 (t, 1H), 4.71 (d, 1H), 4.09 (m, 1H), 3.95 (d, 1H), 3.02 (m, 2H), 2.39 (m, 6H), 2.15 (m, 1H), 1.96 (m, 1H), 1.80 (m, 3H), 1.40 (m, 11H), 0.96 (m, 1H), 0.80 (m, 6H). LC: 100%. MS (M+H+): 530.

Sources & evidence

ORD record
ord-ffd41732ba354385bc643e0adf135cde
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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