4,4-Bis(4-fluorophenyl)butyric acid → HCID 68983959, compound

HRID 1467885Notes

Reaction equation

HRID 1467885 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=2)[CH2:32][CH2:33][C:34](O)=[O:35])=[CH:27][CH:26]=1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:34](=[O:35])[CH2:33][CH2:32][CH:31]([C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=3)[C:28]3[CH:29]=[CH:30][C:25]([F:24])=[CH:26][CH:27]=3)[CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)(=[O:6])=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 886374,4-Bis(4-fluorophenyl)butyric acidHCID 2773944N-Cyclopropyl-N-piperidin-4-yl-3-(trifluoromethyl)benzenesulfonamide

Product 1

HCID 68983959HCID 68983959, compound

Procedure

N-Cyclopropyl-N-{1-[4,4-bis(4-fluorophenyl)butanoyl]piperidin-4-yl}-3-trifluoromethylbenzenesulfonamide was prepared from N-cyclopropyl-N-(piperidin-4-yl)-3-trifluoromethylbenzenesulfonamide and 4,4-bis(4-fluorophenyl)butanoic acid. LC: 100%. MS: m/z=607 (M+H+). 1H NMR (CDCl3): δ 8.12 (1H, s), 8.04 (1H, d), 7.86 (1H, d), 7.69 (1H, t), 7.16 (4H, dd), 6.98 (4H, dd), 4.71 (1H, d), 3.98 (1H, d), 3.80 (1H, t), 3.68 (1H, d), 2.91 (1H, t), 2.50 (1H, t), 2.33 (2H, m), 2.21 (2H, m), 1.93 (1H, m), 1.75 (4H, m), 0.91 (4H, m);

Sources & evidence

ORD record
ord-bde6926dbf964e18a1a833f5396e1fae
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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