4,4-Bis(4-fluorophenyl)butyric acid → HCID 68984220, compound

HRID 1467886Notes

Reaction equation

HRID 1467886 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]([F:17])([F:16])[F:15])(=[O:7])=[O:6])[CH2:3][CH2:2]1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=2)[CH2:32][CH2:33][C:34](O)=[O:35])=[CH:27][CH:26]=1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:34](=[O:35])[CH2:33][CH2:32][CH:31]([C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=3)[C:28]3[CH:29]=[CH:30][C:25]([F:24])=[CH:26][CH:27]=3)[CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]([F:17])([F:15])[F:16])(=[O:6])=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 886374,4-Bis(4-fluorophenyl)butyric acidHCID 68985568HCID 68985568, compound

Product 1

HCID 68984220HCID 68984220, compound

Procedure

N-Cyclopropyl-N-{1-[4,4-bis(4-fluorophenyl)butanoyl]piperidin-4-yl}-2-trifluoromethylbenzenesulfonamide was prepared from N-cyclopropyl-N-(piperidin-4-yl)-2-trifluoromethylbenzenesulfonamide and 4,4-bis(4-fluorophenyl)butanoic acid which can be prepared according to Sindelar et al. (Collection of Czechoslovak Chemical Communications 38(12): 3879-3901 (1973)). LC: 100%. MS: m/z=607 (M+H+). 1H NMR (CDCl3): δ 8.29 (1H, d), 7.88 (1H, d), 7.72 (2H, m), 7.18 (4H, dd), 6.98 (4H, dd), 4.76 (1H, d), 4.25 (1H, m), 3.95 (1H, m), 3.72 (1H, d), 3.00 (1H, t), 2.55 (1H, t), 2.30 (5H, m), 1.84 (4H, m), 0.61 (2H, m), 0.49 (1H, m), 0.36 (1H, m); and

Workup

  1. customcan be prepared
  2. customaccording to Sindelar et al. (Collection of Czechoslovak Chemical Communications 38(12): 3879-3901 (1973))

Sources & evidence

ORD record
ord-6d74458ac0754b198059661ba72e4a3a
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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