4,4-Bis(4-fluorophenyl)butyric acid → HCID 68984220, compound

Participants

Reaction Steps

N-Cyclopropyl-N-{1-[4,4-bis(4-fluorophenyl)butanoyl]piperidin-4-yl}-2-trifluoromethylbenzenesulfonamide was prepared from N-cyclopropyl-N-(piperidin-4-yl)-2-trifluoromethylbenzenesulfonamide and 4,4-bis(4-fluorophenyl)butanoic acid which can be prepared according to Sindelar et al. (Collection of Czechoslovak Chemical Communications 38(12): 3879-3901 (1973)). LC: 100%. MS: m/z=607 (M+H+). 1H NMR (CDCl3): δ 8.29 (1H, d), 7.88 (1H, d), 7.72 (2H, m), 7.18 (4H, dd), 6.98 (4H, dd), 4.76 (1H, d), 4.25 (1H, m), 3.95 (1H, m), 3.72 (1H, d), 3.00 (1H, t), 2.55 (1H, t), 2.30 (5H, m), 1.84 (4H, m), 0.61 (2H, m), 0.49 (1H, m), 0.36 (1H, m); and

Provenance & Evidence