Phenylboronic Acid → HCID 51038834, compound

HRID 1467934Notes

Reaction equation

[C:1](=[O:26])([O:7][C:8]1[N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:11]=[C:10]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21](I)[CH:20]=2)[CH:9]=1)[O:2][C:3]([CH3:6])([CH3:5])[CH3:4].[CH2:27]([O:34][C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C1(B(O)O)C=CC=CC=1>>[C:1](=[O:26])([O:2][C:3]([CH3:6])([CH3:5])[CH3:4])[O:7][C:8]1[N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:11]=[C:10]([C:19]2[CH:20]=[C:21]([C:38]3[CH:39]=[CH:40][C:35]([O:34][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:36][CH:37]=3)[CH:22]=[CH:23][CH:24]=2)[CH:9]=1

Participants

Reactant 3

HCID 66827Phenylboronic Acid

HCID 27343144-Benzyloxy-phenylboronic acid

HCID 51038614HCID 51038614, compound

Product 1

HCID 51038834HCID 51038834, compoundYield 99%

Procedure

The title compound was prepared in the same manner as in Example C-1, except that an equimolar amount of each of 3-(3-iodophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-yl tert-butyl carbonate (23) prepared in Example B-4 and 4-benzyloxyphenylboronic acid (manufactured by Aldrich) was used in place of Compound 21 prepared in Example B-2 and phenylboronic acid.

Sources & evidence

ORD record: ord-a4f5bd4513f64d388075c27f5c820353
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000176B2

Reaction notes

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