2-Chloro-5-hydroxypyridine → tert-Butyl 4-{[(6-chloropyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

HRID 1467979Notes

Reaction equation

HRID 1467979 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1.[Cl:16][C:17]1[N:22]=[CH:21][C:20](O)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[N:22]=[CH:21][C:20]([O:1][CH2:2][CH:3]2[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 8198212-Chloro-5-hydroxypyridineHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 59718534tert-Butyl 4-{[(6-chloropyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Intermediate-6 using tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate and 6-chloropyridin-3-ol (0.10 g, 54%); MS: 271 (M−56).

Sources & evidence

ORD record
ord-b647e7fdf416483196ac7d961816f7c3
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

Loading…