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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1467979Generated: October 27, 2026

2-Chloro-5-hydroxypyridine → tert-Butyl 4-{[(6-chloropyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

https://huagongshe.com/reaction/1467979

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-hydroxypyridineHCID 819821—
ReactantTert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 2764081—
Producttert-Butyl 4-{[(6-chloropyridin-3-yl)oxy]methyl}piperidine-1-carboxylateHCID 59718534—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Intermediate-6 using tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate and 6-chloropyridin-3-ol (0.10 g, 54%); MS: 271 (M−56).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-b647e7fdf416483196ac7d961816f7c3
Source noteuspto-grants-2015_04