N-(1H-indol-5-yl)pivalamide → tert-Butyl 4-((6-(5-pivalamido-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylate

HRID 1467980Notes

Reaction equation

HRID 1467980 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[NH:22]1[C:30]2[C:25](=[CH:26][C:27]([NH:31][C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:28][CH:29]=2)[CH:24]=[CH:23]1>>[C:32]([NH:31][C:27]1[CH:26]=[C:25]2[C:30](=[CH:29][CH:28]=1)[N:22]([C:2]1[N:7]=[CH:6][C:5]([O:8][CH:9]3[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]3)=[CH:4][CH:3]=1)[CH:23]=[CH:24]2)(=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34]

Participants

3

Reactant 2

HCID 11171956N-(1H-indol-5-yl)pivalamideHCID 86696180Tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate

Product 1

HCID 86696182tert-Butyl 4-((6-(5-pivalamido-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Intermediate-27, using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate and N-(1H-indol-5-yl)pivalamide; MS: 437.6 (M−56).

Sources & evidence

ORD record
ord-6112ea0a944f42ca9fb946fdf229e172
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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