5-(Methanesulfonyl)-2,3-dihydro-1H-indole → tert-Butyl 4-((6-(5-(methylsulfonyl)indolin-1-yl)pyridin-3-yl)amino)-piperidine-1-carboxylate
Reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:22][S:23]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH2:30][CH2:29]2)(=[O:25])=[O:24]>>[CH3:22][S:23]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]3[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]3)=[CH:4][CH:3]=1)[CH2:30][CH2:29]2)(=[O:25])=[O:24]Participants
3
Procedure
The title compound was prepared by following the similar procedure as described in Intermediate-27 using tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate and 5-(methyl-sulfonyl)indoline; MS: 473.3 (M+1).
Sources & evidence
- ORD record
- ord-8cca5f9dcb8941b8ac71b0572aaf9f85
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000175B2
Reaction notes
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