5-N-Boc-amino-1H-indole → 1-(2-((1-(5-ethylpyrazin-2-yl)piperidin-4-yl)oxy)thiazol-4-yl)-1H-indol-5-amine
Reaction equation
Br[C:2]1[N:3]=[C:4]([O:7][CH:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[N:18][C:17]([CH2:20][CH3:21])=[CH:16][N:15]=3)[CH2:10][CH2:9]2)[S:5][CH:6]=1.C(OC(=O)[NH:28][C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][CH:37]=1)[NH:34][CH:33]=[CH:32]2)(C)(C)C>>[CH2:20]([C:17]1[N:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[S:5][CH:6]=[C:2]([N:34]4[C:35]5[C:31](=[CH:30][C:29]([NH2:28])=[CH:37][CH:36]=5)[CH:32]=[CH:33]4)[N:3]=3)[CH2:9][CH2:10]2)=[N:15][CH:16]=1)[CH3:21]Participants
3
Procedure
The title compound was prepared by following the similar procedure as described in Intermediate-27 using 4-bromo-2-((1-(5-ethylpyrazin-2-yl)piperidin-4-yl)oxy)thiazole and tert-butyl-1H-indol-5-ylcarbamate (0.092 g, 40%); MS: 421.2 (M+1).
Sources & evidence
- ORD record
- ord-c142fde7752b4c1c81c003bfe4df6f56
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000175B2
Reaction notes
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