5-N-Boc-amino-1H-indole → tert-Butyl 4-((4-(5-amino-1H-indol-1-yl)thiazol-2-yl)oxy)-piperidine-1-carboxylate

HRID 1467985Notes

Reaction equation

HRID 1467985 reaction equation
Br[C:2]1[N:3]=[C:4]([O:7][CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[S:5][CH:6]=1.[NH:21]1[C:29]2[C:24](=[CH:25][C:26]([NH:30]C(=O)OC(C)(C)C)=[CH:27][CH:28]=2)[CH:23]=[CH:22]1>>[NH2:30][C:26]1[CH:25]=[C:24]2[C:29](=[CH:28][CH:27]=1)[N:21]([C:2]1[N:3]=[C:4]([O:7][CH:8]3[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]3)[S:5][CH:6]=1)[CH:22]=[CH:23]2

Participants

3

Reactant 2

HCID 114589235-N-Boc-amino-1H-indoleHCID 86696185tert-Butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate

Product 1

HCID 67616897tert-Butyl 4-((4-(5-amino-1H-indol-1-yl)thiazol-2-yl)oxy)-piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Intermediate-27 using tert-butyl 4((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate and tert-butyl 1H-indol-5-ylcarbamate; MS: 415.1 (M+1).

Sources & evidence

ORD record
ord-f328571a1a484a539f8422c25a2aa829
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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