Tert-butyl 4-hydroxypiperidine-1-carboxylate → tert-Butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate

HRID 1467991Notes

Reaction equation

HRID 1467991 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.Br[C:16]1[S:17][CH:18]=[C:19]([Br:21])[N:20]=1>>[Br:21][C:19]1[N:20]=[C:16]([O:1][CH:2]2[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7]2)[S:17][CH:18]=1

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 27632972,4-Dibromo-1,3-thiazole

Product 1

HCID 86696185tert-Butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Intermediate-42 using tert-butyl 4-hydroxypiperidine-1-carboxylate and 2,4-dibromothiazole (0.1 g, 25%); MS: 363.2 (M+1).

Sources & evidence

ORD record
ord-fea8bfd9d6ce458091ba79bbfef08223
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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