ethyl 1H-indol-5-ylcarbamate → tert-Butyl-4-((6-(5-((ethoxycarbonyl)amino)-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylate
Reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[NH:22]1[C:30]2[C:25](=[CH:26][C:27]([NH:31][C:32](=[O:36])[O:33][CH2:34][CH3:35])=[CH:28][CH:29]=2)[CH:24]=[CH:23]1>>[C:18]([O:17][C:15]([N:12]1[CH2:13][CH2:14][CH:9]([O:8][C:5]2[CH:6]=[N:7][C:2]([N:22]3[C:30]4[C:25](=[CH:26][C:27]([NH:31][C:32]([O:33][CH2:34][CH3:35])=[O:36])=[CH:28][CH:29]=4)[CH:24]=[CH:23]3)=[CH:3][CH:4]=2)[CH2:10][CH2:11]1)=[O:16])([CH3:21])([CH3:20])[CH3:19]Participants
3
Procedure
The title compound was prepared by following the similar procedure as described in Example-1 using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate (intermediate-06) and ethyl 1H-indol-5-ylcarbamate (intermediate-52) (6.0 g, 35%).
Sources & evidence
- ORD record
- ord-09d6530936d64743bca38b3b917244ea
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000175B2
Reaction notes
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