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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468018Generated: October 27, 2026

ethyl 1H-indol-5-ylcarbamate → tert-Butyl-4-((6-(5-((ethoxycarbonyl)amino)-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/1468018

Reaction equation

Participants

RoleNameHCIDCharge
Reactantethyl 1H-indol-5-ylcarbamateHCID 54033885—
ReactantTert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylateHCID 86696180—
Producttert-Butyl-4-((6-(5-((ethoxycarbonyl)amino)-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylateHCID 86696194—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Example-1 using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate (intermediate-06) and ethyl 1H-indol-5-ylcarbamate (intermediate-52) (6.0 g, 35%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-09d6530936d64743bca38b3b917244ea
Source noteuspto-grants-2015_04