5-(Methylsulfonyl)-1H-indole → tert-Butyl-4-((4-(5-(methylsulfonyl)-1H-indol-1-yl)thiazol-2-yl)oxy)-piperidine-1-carboxylate

HRID 1468063Notes

Reaction equation

HRID 1468063 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)(=[O:4])=[O:3].Br[C:15]1[N:16]=[C:17]([O:20][CH:21]2[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]2)[S:18][CH:19]=1>>[C:30]([O:29][C:27]([N:24]1[CH2:23][CH2:22][CH:21]([O:20][C:17]2[S:18][CH:19]=[C:15]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)[N:16]=2)[CH2:26][CH2:25]1)=[O:28])([CH3:33])([CH3:31])[CH3:32]

Participants

3

Reactant 2

HCID 149732305-(Methylsulfonyl)-1H-indole2×HCID 86696185tert-Butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate2×

Product 1

HCID 67616621tert-Butyl-4-((4-(5-(methylsulfonyl)-1H-indol-1-yl)thiazol-2-yl)oxy)-piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate 21) and tert-butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate (intermediate 46) (0.007 g, 5%).

Sources & evidence

ORD record
ord-b9c915ec017945bfa065e6ed77286cdf
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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