5-(1H-1,2,4-triazol-1-yl)-1H-indole → tert-Butyl-4-((4-(5-(1H-1,2,4-triazol-1-yl)-1H-indol-1-yl)thiazol-2-yl) oxy)piperidine-1-carboxylate
Reaction equation
Br[C:2]1[N:3]=[C:4]([O:7][CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[S:5][CH:6]=1.[N:21]1([C:26]2[CH:27]=[C:28]3[C:32](=[CH:33][CH:34]=2)[NH:31][CH:30]=[CH:29]3)[CH:25]=[N:24][CH:23]=[N:22]1>>[C:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][CH:8]([O:7][C:4]2[S:5][CH:6]=[C:2]([N:31]3[C:32]4[C:28](=[CH:27][C:26]([N:21]5[CH:25]=[N:24][CH:23]=[N:22]5)=[CH:34][CH:33]=4)[CH:29]=[CH:30]3)[N:3]=2)[CH2:9][CH2:10]1)=[O:15])([CH3:20])([CH3:19])[CH3:18]Participants
3
Procedure
The title compound was prepared by following the similar procedure as described in Example-1 using tert-Butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate (intermediate 46) and 5-(1H-1,2,4-triazol-1-yl)-1H-indole (intermediate 58).
Sources & evidence
- ORD record
- ord-bc08b4450d8f41b99323a2b9316254d8
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000175B2
Reaction notes
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