Phosphorus oxychloride → 4-[5-(3-Iodo-benzyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile

Participants

Reaction Conditions

Reaction Steps

Suspend 4-cyano-benzoic acid N′-[2-(3-iodo-phenyl)-acetyl]-hydrazide (0.50 g, 1.23 mmol) in phosphorous oxychloride (2.00 mL, 21.0 mmol) and heat at 110° C. for 1 h, resulting in complete dissolution. Cool the mixture to room temperature, pour into ice water and stir until all of the ice melts resulting in a solid precipitate. Collect the formed solid by filtration, wash with H2O and dry on the filter pad to provide 0.37 g 77% yield of 4-[5-(3-iodo-benzyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile as a powder.

Provenance & Evidence