反应详情

温度

110 °C

Suspend 4-cyano-benzoic acid N′-[2-(3-iodo-phenyl)-acetyl]-hydrazide (0.50 g, 1.23 mmol) in phosphorous oxychloride (2.00 mL, 21.0 mmol) and heat at 110° C. for 1 h, resulting in complete dissolution. Cool the mixture to room temperature, pour into ice water and stir until all of the ice melts resulting in a solid precipitate. Collect the formed solid by filtration, wash with H2O and dry on the filter pad to provide 0.37 g 77% yield of 4-[5-(3-iodo-benzyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile as a powder.

1. customresulting in complete dissolution
2. temperatureCool the mixture to room temperature
3. custommelts resulting in a solid precipitate
4. customCollect the formed solid
5. filtrationby filtration
6. washwash with H2O
7. customdry on the filter pad