Sodium Hydroxide → HCID 67507911, compound

Participants

Reaction Steps

Stir a solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4,4-difluoro-piperidine (2.41 g, 9.22 mmol) in 4 mL of 6M hydrochloric acid at room temperature for 48 h. Neutralize the mixture with the addition of 30% NaOH solution and extract with 5×CH2Cl2. Dry the combined extracts with MgSO4 and evaporate to give 1.93 g, 96% yield of 4-(4,4-difluoro-piperidin-1-yl)-cyclohexanone as a colorless liquid.

Provenance & Evidence