Sodium Hydroxide → HCID 67507911, compound

HRID 1468186Notes

Reaction equation

HRID 1468186 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([N:11]3[CH2:16][CH2:15][C:14]([F:18])([F:17])[CH2:13][CH2:12]3)[CH2:7][CH2:6]2)[O:4]CC1.[OH-].[Na+]>Cl>[F:18][C:14]1([F:17])[CH2:15][CH2:16][N:11]([CH:8]2[CH2:7][CH2:6][C:5](=[O:4])[CH2:10][CH2:9]2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69643342HCID 69643342, compound

Product 1

HCID 67507911HCID 67507911, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Stir a solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4,4-difluoro-piperidine (2.41 g, 9.22 mmol) in 4 mL of 6M hydrochloric acid at room temperature for 48 h. Neutralize the mixture with the addition of 30% NaOH solution and extract with 5×CH2Cl2. Dry the combined extracts with MgSO4 and evaporate to give 1.93 g, 96% yield of 4-(4,4-difluoro-piperidin-1-yl)-cyclohexanone as a colorless liquid.

Workup

  1. extractionextract with 5×CH2Cl2
  2. dry with materialDry the combined extracts with MgSO4
  3. customevaporate

Sources & evidence

ORD record
ord-8ec69af20ac44019868e8c963411c0c7
Source dataset
uspto-grants-2015_04
Patent number
US09000154B2

Reaction notes

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