Hydrochloric Acid → HCID 86710018, compound

Participants

Reaction Conditions

Reaction Steps

Compound 1 (947 mg, 2.46 mmol) was suspended in a 50% ethanol aqueous solution (10 mL), and the suspension was stirred at 50° C. for 1 hour after adding lithium hydroxide.1 hydrate (130 mg, 3.10 mmol). Under ice-cooled condition, 3 mol/L hydrochloric acid was added to the reaction mixture. The precipitated solid was collected by filteration, and dried under reduced pressure to give 3-cyclohexylmethyl-7-(N,N-diethylcarbamoyl)imidazo[1,2-a]pyridine-2-carboxylic acid (579 mg, yield 66%).

Provenance & Evidence