Hydrochloric Acid → HCID 86710018, compound

HRID 1468256Notes

Reaction equation

HRID 1468256 reaction equation
[CH:1]1([CH2:7][C:8]2[N:12]3[CH:13]=[CH:14][C:15]([C:17](=[O:23])[N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[CH:16][C:11]3=[N:10][C:9]=2[C:24]([O:26]CC)=[O:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Li+].Cl>C(O)C>[CH:1]1([CH2:7][C:8]2[N:12]3[CH:13]=[CH:14][C:15]([C:17](=[O:23])[N:18]([CH2:19][CH3:20])[CH2:21][CH3:22])=[CH:16][C:11]3=[N:10][C:9]=2[C:24]([OH:26])=[O:25])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86710015HCID 86710015, compound

Product 1

HCID 86710018HCID 86710018, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

Compound 1 (947 mg, 2.46 mmol) was suspended in a 50% ethanol aqueous solution (10 mL), and the suspension was stirred at 50° C. for 1 hour after adding lithium hydroxide.1 hydrate (130 mg, 3.10 mmol). Under ice-cooled condition, 3 mol/L hydrochloric acid was added to the reaction mixture. The precipitated solid was collected by filteration, and dried under reduced pressure to give 3-cyclohexylmethyl-7-(N,N-diethylcarbamoyl)imidazo[1,2-a]pyridine-2-carboxylic acid (579 mg, yield 66%).

Workup

  1. additionwas added to the reaction mixture
  2. customThe precipitated solid was collected by filteration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-56f0c63fb5404fd0b59375abeade6262
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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