HCID 86710068, compound → HCID 86710067, compound

HRID 1468276Notes

Reaction equation

HRID 1468276 reaction equation
[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH:5]([CH:8]=[CH:9][C:10]([C:12]2([C:15]([F:18])([F:17])[F:16])[CH2:14][CH2:13]2)=[O:11])[CH2:4][CH2:3]1>C(O)C.[Pd]>[F:1][C:2]1([F:19])[CH2:3][CH2:4][CH:5]([CH2:8][CH2:9][C:10]([C:12]2([C:15]([F:16])([F:17])[F:18])[CH2:13][CH2:14]2)=[O:11])[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 86710068HCID 86710068, compound

Product 1

HCID 86710067HCID 86710067, compoundYield 95.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3-(4,4-Difluorocyclohexyl)-1-(1-trifluoromethylcyclopropyl)propan-2-en-1-one (0.746 g, 2.64 mmol) obtained in step 2 was dissolved in ethanol (10 mL), and allowed to react at 25° C. in the full H2 mode of an H-cube (registered trademark) using 10% Pd/C CatCart (30 mm) (ThalesNano Technologies) to give 3-(4,4-difluorocyclohexyl)-1-(1-trifluoromethylcyclopropyl)propan-1-one (0.715 g, yield 95%).

Workup

  1. customto react at 25° C. in the full H2 mode of an H-cube (registered trademark)

Sources & evidence

ORD record
ord-6f82496ea4274fbe9d6b71d7e6b11a36
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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