Aniline → 2-Amino-3-chloro-4-pyridinecarbonitrile

HRID 1468289Notes

Reaction equation

HRID 1468289 reaction equation
Cl[C:2]1[C:3]([C:24]([NH:26]C2C=CC=CC=2)=O)=[CH:4][C:5]2[N:6](C(CC3CCC(F)(F)CC3)=C(C(F)(F)F)[N:10]=2)[CH:7]=1.[Cl:33]C1C(C(O)=O)=CC2N(C(CC3CCC(F)(F)CC3)=C(C(F)(F)F)N=2)C=1.NC1C=CC=CC=1>>[NH2:10][C:5]1[C:4]([Cl:33])=[C:3]([C:24]#[N:26])[CH:2]=[CH:7][N:6]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 89953962HCID 89953962, compoundHCID 89954197HCID 89954197, compound

Product 1

HCID 867100972-Amino-3-chloro-4-pyridinecarbonitrile

Procedure

Compound 107 (40.9 mg, yield 69%) was obtained in the same manner as in step 4 of Example 21, using 6-chloro-3-(4,4-difluorocyclohexylmethyl)-2-trifluoromethylimidazo[1,2-a]pyridine-7-carboxylic acid obtained in step 3, and aniline.

Sources & evidence

ORD record
ord-adcdd64cbf7b454cbff2bb774dce4920
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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