反应详情

温度

100 °C

The 2-isopropylimidazo[1,2-a]pyridine-7-carbonitrile (2.00 g, 10.8 mmol) obtained in step 1 of Example 7 was dissolved in dichloroethane (22 mL). Under ice-cooled condition, trimethylsilyl chlorosulfonate (4.08 g, 21.6 mmol) was added, and the mixture was stirred at 100° C. for hours. The solvent was evaporated under reduced pressure, and the residue was slurried in heptane. The resulting crystals were collected by filteration to give 7-cyano-2-isopropylimidazo[1,2-a]pyridine-3-sulfonic acid (2.71 g, yield 95%).

1. additionwas added
2. customThe solvent was evaporated under reduced pressure
3. customThe resulting crystals were collected by filteration