Einecs 211-027-4 → HCID 13314045, compound

HRID 1468591Notes

Reaction equation

HRID 1468591 reaction equation
[Cl-].[NH+]1C=CC=CC=1.C[O:9][C:10]1[C:11]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:12][CH:13]=[CH:14][CH:15]=1>Cl>[C:17]1([NH:16][C:11]2[C:10]([OH:9])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 69401Einecs 211-027-4HCID 23458048HCID 23458048, compound

Product 1

HCID 13314045HCID 13314045, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
200 °C

Procedure

1 L 3-neck flask is charged with Pyridinium chloride (52.2 g, 452 mmol) and 3-methoxy-N-phenylpyridine-2-amine (9 g, 45.2 mmol). The reaction mixture is heated to 200° C. for 4 h. The reaction mixture is dumped into 5% HCl (200 mL), and extracted with 3×300 mL ETOAC. The organic portion is combined and purified by column chromatography (100% DCM) to yield the desired product.

Workup

  1. extractionextracted with 3×300 mL ETOAC
  2. custompurified by column chromatography (100% DCM)

Sources & evidence

ORD record
ord-a34da905ff9c40ef98b7082113c08c78
Source dataset
uspto-grants-2015_04
Patent number
US09005772B2

Reaction notes

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