Hydrazine hydrate (1:1) → HCID 66824634, compound

HRID 1468611Notes

Reaction equation

HRID 1468611 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:15])[C:7](=[O:14])[N:8]2[CH2:11][CH2:12][OH:13])=[C:4](Cl)[N:3]=1.O.[NH2:18][NH2:19]>C(O)C>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:15])[C:7](=[O:14])[N:8]2[CH2:11][CH2:12][OH:13])=[C:4]([NH:18][NH2:19])[N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86696632HCID 86696632, compound

Product 1

HCID 66824634HCID 66824634, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
105 °C

Procedure

A mixture of 2-amino-6-chloro-9-(2-hydroxyethyl)-7-methyl-purin-8-one obtained in step 3 (8 g, 32.9 mmol), Hydrazine hydrate (16 ml, 32.9 mmol) and ethanol (300 ml) were heated at 100-110° C. for 16 hours. The reaction mixture was concentrated and solid obtained was filtered off and dried to obtain 2-amino-6-hydrazino-9-(2-hydroxyethyl)-7-methyl-purin-8-one (7 g, 89%) as an off white solid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customsolid obtained
  3. filtrationwas filtered off
  4. customdried

Sources & evidence

ORD record
ord-217646fb081040968f451eef9125ef17
Source dataset
uspto-grants-2015_04
Patent number
US09006177B2

Reaction notes

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