Hydrazine hydrate (1:1) → HCID 66824447, compound

HRID 1468623Notes

Reaction equation

HRID 1468623 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:23])[C:7](=[O:22])[N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[C:4](Cl)[N:3]=1.O.[NH2:26][NH2:27]>C(O)C>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:23])[C:7](=[O:22])[N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[C:4]([NH:26][NH2:27])[N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86696639HCID 86696639, compound

Product 1

HCID 66824447HCID 66824447, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
92.5 °C

Procedure

A mixture of 2-amino-6-chloro-9-[(3,4-dimethoxyphenyl)methyl]-7-methyl-purin-8-one obtained in step 3 (9.0 g, 25.73 mmol), Hydrazine hydrate (16 ml, 257.3 mmol) and ethanol (675 ml) were heated at 90-95° C. for 40 hours. The reaction mixture was concentrated and solid obtained was filtered off and dried to obtain 2-amino-9-[(3,4-dimethoxyphenyl)methyl]-6-hydrazino-7-methyl-purin-8-one (6.5 g, 74%) as an off white solid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customsolid obtained
  3. filtrationwas filtered off
  4. customdried

Sources & evidence

ORD record
ord-cebf93ab04c740a985b197c1218e9728
Source dataset
uspto-grants-2015_04
Patent number
US09006177B2

Reaction notes

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