Cyclopropanemethanamine → HCID 71468903, compound

HRID 1468652Notes

Reaction equation

HRID 1468652 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:8]=[C:7]([F:15])[CH:6]=1.[NH2:16][CH2:17][CH:18]1[CH2:20][CH2:19]1.FC1C=C(C=C(S(C)(=O)=O)C=1)OCCNCCC>C(O)C>[CH:18]1([CH2:17][NH:16][CH2:2][CH2:3][O:4][C:5]2[CH:10]=[C:9]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:8]=[C:7]([F:15])[CH:6]=2)[CH2:20][CH2:19]1

Participants

5

Reactant 3

HCID 75646CyclopropanemethanamineHCID 709804851-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-HCID 86717739HCID 86717739, compound

Product 1

HCID 71468903HCID 71468903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene (0.05 g, 0.16 mmol) and aminomethylcyclopropane (0.11 ml, 1.3 mmol) in ethanol (5 ml). MS m/z (relative intensity, 70 eV) 287 (M+, 2), 246 (6), 138 (2), 84 (bp), 56 (14).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-8bfe252a05ef4cdb87382d89901bd261
Source dataset
uspto-grants-2015_04
Patent number
US09006227B2

Reaction notes

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