Potassium Carbonate → HCID 70979856, compound

HRID 1468659Notes

Reaction equation

HRID 1468659 reaction equation
Br[C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH3:10][S:11]([O-:13])=[O:12].[Na+].N1CCC[C@H]1C(O)=O.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[Cl:8][C:6]1[CH:5]=[C:4]([OH:9])[CH:3]=[C:2]([S:11]([CH3:10])(=[O:13])=[O:12])[CH:7]=1

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 145742L-ProlineHCID 2733271Sodium methanesulfinateHCID 226301803-Bromo-5-chlorophenol

Product 1

HCID 70979856HCID 70979856, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Preparation according to Preparation 1: 3-bromo-5-chlorophenol (4.0 g, 19.3 mmol), sodium methanesulfinate (3.1 g, 28.9 mmol), cupper(I)iodide (2.2 g, 11.5 mmol), L-proline (2.7 g, 23.1 mmol), potassium carbonate (1.6 g, 11.6 mmol), dry dimethyl sulfoxide (70 ml). Yield: 3.7 g (92%). MS m/z (relative intensity, 70 eV) 206 (M+, 88), 191 (36), 144 (58), 127 (bp), 99 (76).

Workup

  1. customPreparation
  2. customaccording to Preparation 1

Sources & evidence

ORD record
ord-c5bcb36cf5ba4e438e85006386bc81a7
Source dataset
uspto-grants-2015_04
Patent number
US09006227B2

Reaction notes

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