5,8-Dibromoimidazo[1,2-a]pyrazine → N-(5-bromoimidazo[1,2-a]pyrazin-8-yl)-5-((tert-butyldimethylsilyloxy)methyl)thiazol-2-amine

HRID 1468813Notes

Reaction equation

HRID 1468813 reaction equation
[Br:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5](Br)=[N:4][CH:3]=1.[Si:12]([O:19][CH2:20][C:21]1[S:25][C:24]([NH2:26])=[N:23][CH:22]=1)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]>>[Br:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5]([NH:26][C:24]2[S:25][C:21]([CH2:20][O:19][Si:12]([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:14])=[CH:22][N:23]=2)=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 534859495,8-Dibromoimidazo[1,2-a]pyrazineHCID 575413285-(((tert-Butyldimethylsilyl)oxy)methyl)thiazol-2-amine

Product 1

HCID 57541342N-(5-bromoimidazo[1,2-a]pyrazin-8-yl)-5-((tert-butyldimethylsilyloxy)methyl)thiazol-2-amine

Procedure

Prepared from Intermediate 2 and Intermediate 7 using the procedure described in Example 1, Step 1. MS (MH+, m/z) 440.

Sources & evidence

ORD record
ord-e776fa2d772041bead1be1f1419ddcfe
Source dataset
uspto-grants-2015_04
Patent number
US09006237B2

Reaction notes

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