HCID 86717786, compound → {(1R,2R)-2-[1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methanol

HRID 1468835Notes

Reaction equation

HRID 1468835 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([C@H:16]3[CH2:18][C@H:17]3[CH2:19][OH:20])[CH2:12][CH2:11]2)=[N:8][CH:9]=1)([CH3:3])=[CH2:2]>CCO.[Pd]>[CH:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([C@H:16]3[CH2:18][C@H:17]3[CH2:19][OH:20])[CH2:12][CH2:11]2)=[N:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 86717786HCID 86717786, compound

Product 1

HCID 71128800{(1R,2R)-2-[1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methanol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The product of step A (170 mg, 0.62 mmol) and 5% Pd/C (20 mg) were dissolved in EtOH (5 mL). The mixture was stirred under 1 atm of H2 for 1 hour. The mixture was filtered and the filtrate concentrated in vacuo, yielding the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-bbdfca2ecc5a4dc8aa1dfb559566d024
Source dataset
uspto-grants-2015_04
Patent number
US09006228B2

Reaction notes

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