Iodide Ion → 2-{4-[(1R,2R)-2-(iodomethyl)cyclopropyl]piperidin-1-yl}-5-isopropylpyrimidine

HRID 1468836Notes

Reaction equation

HRID 1468836 reaction equation
[CH:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([C@H:16]3[CH2:18][C@H:17]3[CH2:19]O)[CH2:12][CH2:11]2)=[N:8][CH:9]=1)([CH3:3])[CH3:2].[I-:21]>>[I:21][CH2:19][C@@H:17]1[CH2:18][C@@H:16]1[CH:13]1[CH2:14][CH2:15][N:10]([C:7]2[N:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][N:8]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 30165Iodide IonHCID 71128800{(1R,2R)-2-[1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methanol

Product 1

HCID 867177872-{4-[(1R,2R)-2-(iodomethyl)cyclopropyl]piperidin-1-yl}-5-isopropylpyrimidine

Procedure

The product of step B was converted to the iodide using the conditions outlined for intermediate 8, step A.

Sources & evidence

ORD record
ord-dbcab2cb3d30481f8542a537e3d1f19c
Source dataset
uspto-grants-2015_04
Patent number
US09006228B2

Reaction notes

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