Hydrochloric Acid → HCID 86717796, compound

HRID 1468859Notes

Reaction equation

HRID 1468859 reaction equation
[F:1][C:2]1[CH:26]=[C:25]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:24]=[CH:23][C:3]=1[CH2:4][O:5][CH2:6][C@@H:7]1[CH2:9][C@@H:8]1[CH:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1.[ClH:31].O1CCOCC1>C(Cl)Cl>[ClH:31].[F:1][C:2]1[CH:26]=[C:25]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:24]=[CH:23][C:3]=1[CH2:4][O:5][CH2:6][C@@H:7]1[CH2:9][C@@H:8]1[CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71136675HCID 71136675, compound

Product 1

HCID 86717796HCID 86717796, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate (Step C product, 1.13 g, 2.56 mmol) was dissolved in DCM (20 ml) and HCl in dioxane (4 M solution, 9.60 ml, 38.4 mmol) was added. The mixture was stirred at RT for 1 h. The solvents were evaporated to afford 0.97 g of the desired product (100%) which will be used without further purification. LC/MS (m/z): 378 (M+H)+.

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-29a925966a2b466b9d735cffef724c08
Source dataset
uspto-grants-2015_04
Patent number
US09006228B2

Reaction notes

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