反应详情

tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate (Step B product, 1.85 g, 4.03 mmol) was dissolved in DCM (20 ml) and HCl in dioxane (4 M solution, 10.60 ml, 40 mmol) was added. The mixture was stirred at RT for 1 h. The solvents were evaporated to afford 1.6 g (100%) of the desired product which was used without further purification. LC/MS (m/z): 360 (M+H)+.

1. customThe solvents were evaporated