Pyrrolidine → HCID 56655852, compound

HRID 1469033Notes

Reaction equation

HRID 1469033 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)=[N:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136379423HCID 136379423, compound

Product 1

HCID 56655852HCID 56655852, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-fluoro-4-oxo-6-(piperidin-1-yl)-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI): predicted mass calcd. for C21H23FN6O2, 410.2

Sources & evidence

ORD record
ord-a70e4cd1bd9c476a94d31f0fc4577c04
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

Loading…